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Your body has a variety of systems in place to keep it running. The cardiovascular system pumps oxygen and other nutrients to your tissues. Your respiratory system brings air into and out of your lungs. Your digestive system helps you break down food and utilize their precious nutrients. Each system plays a critical role in keeping you healthy.
But did you know your body also has an endocannabinoid system?
Even though most people are unaware of this system, it has a huge impact on your mental and physical health. In fact, the endocannabinoid system (ECS) is regarded as “the most important physiologic system involved in establishing and maintaining human health” (1).
Bold statement, but it’s true. This is partly why hemp oil supplements with CBD have become so popular—because evidence suggests they support the endocannabinoid system (2).
Once you learn about how the ECS works and how it affects your body, taking cannabinoid-rich hemp oil becomes a no-brainer.
The endocannabinoid system is a complex network of receptors, receptor molecules, and enzymes. Components of the ECS can be found throughout your entire body. This includes your immune system, brain, gut, and central nervous system.
Parts of the Endocannabinoid System: The endocannabinoid system consists of three primary components:
Cannabinoid receptors: Structures found on the surface of cells. When activated, they stimulate the ECS.
Cannabinoids: Molecules that specifically bind to and activate cannabinoid receptors.
Enzymes: Breaks down cannabinoids once they’re no longer needed.
Cannabinoid receptors can be found all throughout your body. They are embedded in the membranes, or surface, of your cells. Receptors are like the ignition of a car. If you have the key that fits, you can start the car and drive. In this case, when a cannabinoid comes along (the key), it binds to the cannabinoid receptors and stimulates the ECS (i.e., starting the car).
The two primary cannabinoid receptors are CB1 and CB2. There are other cannabinoid receptors, but these two are the most well-studied. CB1 receptors are primarily found in the central nervous system which includes your brain and spinal cord (3). As such, the CB1 receptor is thought to regulate anxiety, stress, learning, memory, and your overall mood (4).
CB2 receptors are predominantly found in cells that are part of the immune system. Which means they primarily affect immune system homeostasis. But they have other roles as well.
Cannabinoids are the molecules that “turn on” the endocannabinoid system by binding to cannabinoid receptors. There are two primary types of cannabinoids that control the ECS: endocannabinoids and phytocannabinoids.
Endocannabinoids are molecules naturally produced by your body. Specifically, your cells produce them on an as-needed basis. The two most prominent cannabinoids are anandamide and 2-arachidonoyl glycerol (2-AG). Both of which have a long list of scientifically supported benefits (5).
Anandamide
Anandamide is a neurotransmitter that’s produced in the brain. Due to its effects on the body, anandamide has earned itself the nickname, “bliss molecule.” That’s because elevated levels of anandamide are often associated with feelings of happiness and well-being. Anandamide is also shown to encourage the growth of new brain cells (6).
2-Arachidonoyl glycerol (2-AG)
2-Arachidonoyl glycerol, or 2-AG, binds to the CB1 and CB2 receptors of the endocannabinoid system. Scientists believe that 2-AG specifically plays a large role in suppressing inflammation by modulating the body’s immune response (7).
Unlike endocannabinoids, phytocannabinoids are not produced in the body. Instead, they are found in cannabis and hemp. Because they stimulate the endocannabinoid system in a similar way to endocannabinoids, hemp oil supplements have become incredibly popular.
Furthermore, evidence suggests that phytocannabinoids exert a wide range of beneficial effects. Studies indicate that cannabinoids may:
They are truly impressive molecules to say the least.
The most common phytocannabinoids include THC, the famous CBD (cannabidiol), cannabichromene, and cannabigerol. While endocannabinoids may provide similar benefits, phytocannabinoids are helpful if your body doesn’t produce enough endocannabinoids on its own.
Enzymes are tiny structures that break down substances in the body. They are an essential part of countless biochemical reactions in the body. For the ECS, enzymes disassemble cannabinoids when they’re no longer needed. This ensures that the ECS isn’t “overstimulated.”
While there are several enzymes involved with the ECS, the two most important ones are FAAH and MAGL. FAAH, or fatty acid amide hydrolase breaks down anandamide. MAGL, or monoacylglycerol lipase, deconstructs 2-AG (14).
With this in mind, the ECS can have a greater effect if these enzymes are temporarily shut down. This is the case with phytocannabinoids like CBD. Scientists believe CBD inhibits the FAAH enzyme which causes the ECS to act with a greater balancing force (15).
The Role of The Endocannabinoid System
Because the ECS is such a vast system, it affects countless systems in the body. It’s like the big boss that controls all of the other systems in your body. The master system, so to speak.
The endocannabinoid system has to be vast in order to carry out its primary role: maintaining homeostasis.
The ECS and Homeostasis
Homeostasis is the continuous process of achieving a state of balance. Think of yin and yang or a set of scales. Homeostasis is all about finding that perfect sweet spot so your body can function in an optimal state.
Maintaining homeostasis, or balance, is key to living a healthy life.
If your blood pressure is too high, it can lead to heart problems. But if it’s too low, your blood won’t circulate as it should.
If your skin produces too much oil, you might get acne. When it doesn’t produce enough, it can get dry.
If your immune system is too weak you will get sick. But if it’s too overactive, it may result in autoimmune disease.
The point is, maintaining homeostasis is incredibly important. And the ECS is the invisible hand that controls homeostasis. To drive the point even further, here are some examples of how the endocannabinoid system helps the body stay in a balanced state.
Your brain has about 100 billion neurons (16). These neurons control basic functions with chemicals called neurotransmitters. This includes functions like talking, moving, breathing, and learning.
Much like any system in the body, your neurons perform best when they are in the homeostatic sweet spot. When the balance of neurotransmitters goes haywire, things can easily go wrong.
For example, an excess of the neurotransmitter norepinephrine can result in chronic stress or anxiety (17). Low levels of norepinephrine, on the other hand, can result in extreme fatigue, a lack of concentration, and a poor mood (18). This is where the endocannabinoid system comes into play.
According to Dr. Ethan Russo, neurologist and medical scientist, the endocannabinoid system regulates “neurotransmitter function … if there’s too much of one kind of neurotransmitter it will bring it down, if there’s too little it will bring it up.” (19)
Inflammation is your body’s natural response to infection or physical injury. In low amounts, it’s beneficial for healing damaged tissue and fighting dangerous microbes that cause illness or disease. Once the infection is eliminated or the injury is healed, the inflammation goes away. Your body then can return to a healthy, balanced state.
But things don’t always go as planned. Sometimes inflammation can persist well after it’s needed. When this happens, it’s called chronic inflammation. Over time, it can wreak havoc on your body (20).
Too much inflammation is harmful, whereas too little will leave your body vulnerable to germs. Much like your brain, evidence suggests the endocannabinoid system helps to control inflammation homeostasis. Or more specifically, the balance of your immune system.
Scientists have found that endocannabinoids regulate the immune system by limiting the immune response (21). It regulates the immune system by signaling the apoptosis of activated immune cells while simultaneously suppressing proinflammatory cells like cytokines and chemokines (22).
Simply put, the ECS may combat chronic inflammation by preventing the immune system from becoming overactive. When the immune system is no longer needed in a given area, cells produce endocannabinoids which tell the immune system to back off.
Imagine homeostasis as a pendulum, depicted at the beginning of this guide. When it swings to the right, you’re stressed. When it swings to the left, you are completely chill.
Maintaining a balance between these two ends of the pendulum is essential. If you’re constantly stressed, it can send your body haywire. On the flip side, if you’re content to stay in your comfort zone, you won’t accomplish much in life. A small amount of stress is actually beneficial.
Evidence suggests that the endocannabinoid system encourages stress homeostasis by playing a role in stress adaptation (23). Adaptogenic herbs like rhodiola rosea work in a similar fashion.
Simply put, the ECS helps you become more resilient to the effects of stress. That way you can quickly return to a state of balance after a stressful event. Researchers have even found that when the ECS is weak, chronic stress will likely follow suit (24).
So, you now know how the endocannabinoid system plays a role in homeostasis, which in turn has a massive impact on your well-being. But what happens when your endocannabinoid system doesn’t work as it should?
Over the past several years, scientists have discovered that the endocannabinoid system can be in a weakened state. When this happens, they call it an endocannabinoid deficiency.
When your body can’t maintain homeostasis due to an endocannabinoid deficiency, it can result in a long list of health issues from headaches, to muscle discomfort, to digestive problems (25). This supports the idea that maintaining homeostasis is absolutely essential for a healthy mind and body.
Hemp oil is an extract of hemp that contains phytocannabinoids like CBD and cannabichromene. Most companies use specific strains of hemp that are rich in CBD to create their oil.
Hemp oil products have become increasingly popular because of their proposed benefits, supplementing the endocannabinoid system with phytocannabinoids (26). While most phytocannabinoids are thought to have beneficial effects, CBD has gained the most attention.
According to the latest research, CBD inhibits the FAAH enzyme, which deconstructs anandamide (15). As a result, taking CBD may increase the amount of anandamide in the body, which can stimulate the ECS. This may explain why hemp oil has such a wide range of benefits.
The endocannabinoid system, or ECS, is a complex network of cannabinoids, receptors, and metabolic enzymes. Its primary role is to help the body and mind maintain homeostasis. In doing so, it keeps countless systems in balance. That way, nothing becomes underactive or overactive. It’s an absolutely essential process for maintaining optimal health.
The problem is, the endocannabinoid system can become weak. When this happens, scientists have predicted that it may result in the development of health problems. This is why phytocannabinoid-rich supplements like hemp oil have become popular, and are projected to become increasingly in demand. The phytocannabinoids affect the ECS, which could result in a wide range of effects due to how the ECS interacts with the body.
Researchers are still trying to fully understand the ECS, how it works, and how cannabinoids affect the body. While phytocannabinoids show promise for their therapeutic effects, this does not mean they are a magic bullet that will cure anything. That being said, hemp oil still remains as an excellent choice for supporting your general health.
Slightly sweet with notes of Matcha green tea and aromatic vanilla bean, this fast and flavorful smoothie comes with 18g of plant protein and powerful antioxidants to fuel energy and recovery. It’s organic, vegan, gluten-free and delicious.
1 cup (8 oz.) unsweetened organic vanilla almond milk ½ cup frozen banana slices (about half a banana) 1 tsp. organic matcha green tea powder 2 scoops Organic Super Protein
Not only do these antioxidants help speed recovery after a workout, EGCG in green tea gives your metabolism a boost too, for natural energy (1).
Organic Super Protein provides 18g of plant protein sourced from organic superfoods including pea, hemp and gluten-free ancient grains.
These proteins combine with energizing MCTs from organic coconut to help satisfy cravings and optimize metabolism. Organic omegas round out the blend, supporting heart health.
Easy to make and a delight to drink, this tasty protein smoothie satisfies your sweet tooth and nutrient needs all in one. Whether you have a tough workday or a tough workout, turn to this tasty shake to power through.
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Take the heat out of summer with a delightful seasonal refresher. Hydrating watermelon hits your sweet spot, while fresh lime cuts through with citrus zing, finishing with minty notes of full spectrum CBD oil. Together it makes this spritzer a fast way to shed any stress so you can savor the best of summer.
True to its name, watermelon is about 92 percent water! That makes it a delicious way to stay hydrated during hot summer months. And its sweet taste comes with the goodness of the antioxidant lycopene. Your immune system also gets support with vitamin C from limes.
CBD (cannabidiol) is a cannabinoid in the hemp plant. Research suggests it has a long list of health benefits for body and mind. Calm Advanced+ CBD Oil features cannabinoid-rich, organically-grown hemp with a refreshing organic peppermint taste.
Mix up a batch of this healthy spritzer to stay hydrated while enjoying long summer days. Not only will it keep you cool, but the splash of CBD will also help you to chill, bringing health and happiness to summer.
Revive your senses and instill a sense of calm and relaxation with this CBD mocktail inspired by the classic mojito. Slightly tart berries blend perfectly with the minty notes of premium CBD oil and fresh herbs. In just minutes, you’ll feel stresses melt away and be ready for whatever comes your way.
2-3 roughly chopped organic strawberries 3-4 loosely torn fresh mint leaves ½ tablespoon organic raw honey 1 tablespoon lime juice 1 mL (one dropperful) Calm Premium CBD Oil ½ cup ginger beer (or your favorite fizzy mixer)
Add strawberries, mint, honey, lime and CBD oil to a glass and muddle well. Add ice, top off with low-sugar ginger beer and stir well for an effervescent, calming mocktail. Garnish with fresh mint and strawberries. Enjoy!
CBD (cannabidiol) is a cannabinoid found in the hemp plant. Research suggests it has a long list of health benefits for body and mind. Calm Premium CBD Oil features cannabinoid-rich, organically-grown hemp and is specially formulated to have zero THC, with a refreshing organic peppermint taste.
Strawberries give a boost of vitamin C for the immune system, while raw honey has enzymes, vitamins, and minerals that bolster natural immunity. The digestive system also gets support from antioxidant-rich mint leaves and natural ginger helps to settle and soothe the stomach.
Mix up a tall glass of calm for every occasion with this refreshing healthy mocktail. A splash of CBD makes this mocktail the perfect way to unwind. Soothe away everyday stress with the minty goodness of broad spectrum CBD oil and feel your best.
Every time you breathe, eat, drink, and touch certain materials, you are exposed to tiny amounts of toxic heavy metals. One day of exposure certainly won’t cause harm. But these heavy metals can accumulate in your body over time and cause substantial damage to your health.
Chronic heavy metal exposure can increase the risk of cardiovascular disease, cause organ toxicity, and promote inflammation. But what most people don’t know is that exposure to heavy metals can have a huge impact on your brain as well—on everything from your mood to memory.
Many heavy metals are what scientists called neurotoxins. This means when they get into your body, they kill nerve and brain cells. The blood-brain barrier normally prevents dangerous compounds from getting to your brain, but heavy metals such as mercury can break through this protective wall.
Once mercury gets into the brain, it causes oxidative stress and inflammation which ultimately can kill off healthy brain cells (1). Scientists have also found that several other heavy metals can kill off brain cells, including lead, cadmium and arsenic (2).
Your memory affects nearly every aspect of your life. It helps you remember important dates, key information related to your job, precious memories, and it’s essential for learning new skills.
This is one of the many reasons why it is important to detoxify heavy metals from your body. Several studies have found that exposure to heavy metals can damage your memory.
Adults who are exposed to lead are shown to have significantly lower learning and memory scores (3). Chronic exposure to lead also appears to result in a progressive decline in memory (4). Arsenic exposure is also linked to deficits in verbal intelligence and long-term memory (5).
Have you ever noticed how much your mood impacts your day-to-day life? When you’re in a great mood, you tend to be more productive, have healthy social interactions, and have more energy. But when you’re feeling down, the exact opposite can happen.
While external events often drive your mood, researchers have found that heavy metals can have a surprising impact on how you feel.
According to the Environmental Protection Agency, mercury exposure can cause mood swings, irritability, nervousness, and excessive shyness (6). Scientists have also discovered that higher levels of lead or cadmium in the blood are associated with depression and anxiety (7, 8).
IQ ratings are the hallmark of cognitive intelligence. Experts agree that you can improve your IQ if you nourish your brain through learning new skills, and getting proper nutrition.
But IQ is not a one-way street. Your IQ can also decrease over time. One way your IQ can be negatively impacted is through chronic heavy metal exposure, especially during childhood.
One study in China, for example, found that children who had higher levels of heavy metals in their blood had significantly lower IQ scores compared to children with fewer heavy metals in their system (9). Other studies clearly show the negative impact of lead exposure on intelligence (3).
Executive function is a term used by scientists to describe several important cognitive functions in the brain. If your executive function is weak, you likely have a hard time paying attention, organizing, controlling your emotions, and resisting distractions.
There are several tactics you can use to strengthen your executive function, with meditation as one of the best methods (10). Another effective strategy is to avoid things that weaken executive function, such as heavy metals. Research has revealed that even low levels of arsenic or lead exposure can compromise your executive function (11, 3).
Your brain and nervous system control fine motor skills. This includes skills that require dexterity like writing, playing musical instruments, texting on a smartphone, or even simple things like turning the pages in a book.
Since heavy metals are known to kill off healthy nerve cells, it makes sense that heavy metals can negatively impact your fine motor skills. Research shows that with mercury exposure, adults typically experience muscle weakness and a loss of overall coordination (12).
But when children are exposed to mercury, it becomes much more problematic. Multiple studies have shown that children and unborn babies can experience developmental delays in fine motor skills when they are exposed to mercury (13).
Mild cognitive decline is a process that typically happens as a result of normal aging. It is most often characterized by decreased memory, language skills, and an impaired ability to think.
Cognitive decline can become much more severe if your brain is chronically inflamed and under constant oxidative stress as it is with heavy metal exposure. When this happens, the symptoms of cognitive decline are magnified, and the brain eventually stops working as it should.
One study suggests that aluminum-contaminated drinking water can intensify cognitive decline and lay the foundation for brain diseases like dementia (14). Another study found that long-term lead exposure is associated with cognitive decline in the elderly (15).
How to Protect Your Brain from Heavy Metals
Now that you know how heavy metals can damage your brain, it’s only natural that you want to avoid this fate. To protect your brain from heavy metals, become aware of the different ways you are exposed to heavy metals.
In addition to avoiding heavy metal exposure, it’s just as important to detoxify heavy metals from the body. Heavy metals remain in your body for exceptionally long periods of time. Cadmium, for instance, stays in your kidneys for up to 38 years (16).
This is why it’s important to detoxify on a regular, even daily basis. That way you can remove accumulated heavy metals from your body so they can no longer cause you harm.
While some foods support detoxification, the best way to target accumulated heavy metals is with the natural mineral zeolite. The zeolite Clinoptilolite is renowned for its ability to selectively bind to toxic heavy metals as it quickly passes through the body. This can provide a simple, effective way to take out toxins on a cellular level, so you can stay sharp in the years ahead.
